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From Luke: People with natural resistance to HIV infection have white blood cells that are more vulnerable to the virus—but they don’t produce many viruses once infected.
Using multiple methods of infection and both single-cycle and replication-competent virus, we show that unmanipulated CD4(+) T-cell populations from ES [resistant patients] are actually more susceptible to HIV-1 infection than those populations from CP [nonresistant patients]. Depletion of highly susceptible cells in CP may contribute to this difference. Using 7AAD and AnnexinV staining, we show that infected cells die more rapidly than uninfected cells, but the increased death of infected cells from CP and ES is proportional. Finally, using an assay for measuring virus production, we show that virus production by cells from CP is high compared with virus production by cells from ES or uninfected donors.